Incidence of Oral Cancer in a Tertiary Cancer Centre of Nepal: A Retrospective Study

  • Pravin Kumar Jaiswal Head & Neck Onchology, Nepal Cancer Hospital & Research Center, Satdobato-Godawari Road, Lalitpur 44700, Nepal.
  • Prabhat Thakur Head & Neck Onchology, Nepal Cancer Hospital & Research Center, Satdobato-Godawari Road, Lalitpur 44700, Nepal. https://orcid.org/0000-0002-2750-0596
  • Kapil Thapa Tri-chandra Multiple Campus, Tribhuvan University, Durbar-Marg, Kathmandu 44600, Nepal. https://orcid.org/0000-0003-2841-4865
Keywords: Tobacco, Cancer Care Facilities, Lip Neoplasms, Incidence, Gingiva, Mouth Neoplasms

Abstract

Background: Oral cancer, which includes cancer of lips, gingiva, tongue, oropharynx, sinuses, and salivary glands, ranks fifth in its kind in Nepal. The incidence of oral cancer may differ among gender, age, and site. This study aims to address the questions regarding the incidence and trend of oral cancer occurrence.
Methods: Oral cancer cases registered in the Head and Neck Oncology Department of Nepal Cancer Hospital & Research Centre, Lalitpur, Nepal from 01 Jan 2018 to 31 Dec 2019 were included in this study. The data were categorized under gender, site of a tumor, year of diagnosis, and age of patients at diagnosis and entered in RStudio version-1.3.1093 for analysis.
Results: A total of 165 cases were found to be recorded where 74.5% were male and 24.5% were female. The most common site was the tongue (27.27%) followed by the mandibular alveolus (19.39%). The overall mean age was 53.71 years (95% CI: 55.73-51.68). The number of new cases was found to be increased by 35.71% from 2018 to 2019.
Conclusion: A significant increase in the number of new cases indicates that there are deficiencies in handling oral cancer in Nepal. Reducing the production, import, and consumption of tobacco and related products as well as ensuring accessible health facilities for all may help control this disease.

References

Siddiqui S, Chandra, R, Aziz, A and Suman, S. Epidemiology and Histopathological Spectrum of Head and Neck Cancers in Bihar; A State of Eastern India. Asian Pacific Journal of Cancer Prevention. 2012; 13: 3949-3953. https://doi.org/10.7314/APJCP.2012.13.8.3949. [Google Scholar] [PubMed]

WebMD. 2017; Oral Cancer. https://www.webmd.com/oral-health/guide/oral-cancer#1. Acessed on 20th July 2019. [Link]

Chovatiya NR, Modi TG, Choksi VA, Shah S, Majeethia D. Oral Squamous Cell Carcinoma Variants- A clinic- pathologic relevance. IOSR Journal of dental and Medical Sciences. 2018; 17(5): 25-30. 10.9790/0853-1705142530 [Google Scholar]

Franco EL, Kowalski, LP, Oliveira, BV, Curado, MP, Pereira, RN, Silva, ME et al. Risk factors for oral cancer in Brazil: A case- control study. International journal of cancer. 1989; 43: 992-1000. https://doi.org/10.1002/ijc.2910430607 [Google Scholar] [PubMed]

Warnakulasuriya S. Global Epidemiology of Oral and Oropharyngeal Cancer. Oral Oncology. 2009; 45: 309-318. https://doi.org/10.1016/j.oraloncology.2008.06.002 [Google Scholar] [PubMed]

GLOBOCON, 2018. Cancer fact sheets. Retrieved from https://gco.iarc.fr/today/fact-sheets-cancers. Accessed on 17 march 2020. [Link]

Sunny L, Yeole BB, Hakama M, Shiri R, Sastry PSRK, Mathews S. et al. Oral Cancers in Mumbai, India: A Fifteen Years Perspective with Respect to Incidence, Trend and Cumulative Risk. Asian Pacific Journal of Cancer Prevention. 2004; 5: 294-300. [Google Scholar] [PubMed]

Nepal Health Research Council. Population based Cancer Registry in Nepal: Interim analysis of data. NHRC.Ramshahpath, Kathmandu, Nepal. 2018. [Link]

Rimal J, Shrestha A, Maharjan IK, Shrestha, S, Shah P. Risk Assessment of Smokeless Tobacco among Oral Precancer and Cancer Patients in Eastern Development Region of Nepal. Asian Pacific Journal of Cancer Prevention. 2019; 20(2): 411-415. https://doi.org/10.31557/APJCP.2019.20.2.411 [Google Scholar] [PubMed]

WHO. International Statistical Classification of Diseases and Related Health Problems (ICD), 10th edition, World Health organization, Geneva. 2018. [Link]

The Comprehensive R Archive Network.Accesssed [2021 February 6] Available from: https://cran.r-project.org/. [Link]

Zhang SK, Zheng R, Chen Q, Zhan S, Sun X, Chen M. Oral Cancer Incidence and Mortality in China. Chin J Cancer Res. 2011; 27(1): 44-51. 10.3978/j.issn.1000-9604.2015.01.03[Google Scholar] [PubMed]

Sugerman PB, Savage NW. Oral cancer in Australia: 1983-1996. Australian Dental Journal. 2002; 47(1): 45-56. https://doi.org/10.1111/j.1834-7819.2002.tb00303.x [Google Scholar] [PubMed]

Tandon P, Diadhich A, Saluja H, Bawane S, Sachdeva S. The Prevalence of Squamous cell Carcinoma in different sites of Oral cavity at our rural Health care centre in loni, Maharastra- a retrospective 10- yearstudy. Contemporary Oncology. 2017; 21(2): 178-183. 10.5114/wo.2017.68628 https://doi.org/10.5114/wo.2017.68628 [Google Scholar] [PubMed]

Mehrotra R, Pandya S, Chaudhary AK, Kumar M, Singh M. Prevalence of oral Pre- malignant and Malignant lesions at a tertiary level Hospital in Allahabad, India. Asian pacific journal of cancer prevention. 2008; 9: 263-266. [Google Scholar] [PubMed]

Byakodi R, Byakodi S, Hiremath S, Byakodi J, Adaki S, Marathe K, et al. Oral cancer in India: An Epidemiologic and Clinical Review. J Community Health. 2011; 37:316-319. https://doi.org/10.1007/s10900-011-9447-6 [Google Scholar] [PubMed]

Poudel KK, Huang Z, Neupane PR, Steel R, Poudel JK. Hospital- based cancer Incidence in Nepal from 2010 to 2013. Nepal Journal of Epidemiology. 2017; 7(1): 659-665. 10.3126/nje.v7i1.17759 https://doi.org/10.3126/nje.v7i1.17759 [Google Scholar] [PubMed]

Luis A, Adriana P, Daniel R. Trend in frequency and prevalence of oral cancer and oral squamous cell carcinoma in Mexicans: A 20 years retrospective study. Oral Medicine and Pathology. 2011; 16(1); 21-25. https://doi.org/10.4317/medoral.16.e1 [Google Scholar] [PubMed]

Phillips PA. The basic science of oncology.1987; Newyork, Pergamon Press, 25 pp [Link]

Bhurgri Y. Cancer of Oral cavity- Trends in Karachi South (1995-2002). Asian Pacific J Cancer Prev. 2005; 6: 22-26. [Google Scholar]

Vatanasapt P, Suwanrungruang K, Kamsaand S, Promthet S, Parkin MD. Epidemiology of oral and pharyngeal cancers in Kon Kaen, Thailand: A high incidence in females. Asian Pacific Journal of Cancer. 2011; 12:2505-2508. [Google Scholar] [PubMed]

Howell RE, Wright BA, Dewar R. Trends in the Incidence of oral cancer in Nova Scotia from 1983 to 1997. Oral Surgery Oral Medicine Oral Pathology. 2003; 95: 205-212. https://doi.org/10.1067/moe.2003.49 [Google Scholar] [PubMed]

Shrestha N, Mehata S, Pradhan PMS, Joshi D, Mishra SR. A nationally representative study on socio-demographic and geographic correlates, and trends in tobacco use in Nepal. Sci Rep. 2019; 9: 2682. https://doi.org/10.1038/s41598-019-39635-y [Google Scholar] [PubMed]

WHO Expert Committee on Recent Advances in Oral Health & World Health Organization. ‎1992‎. Recent advances in oral health: report of a WHO expert committee [‎meeting held in Geneva from 3 to 9 December 1991]‎. World Health Organization. https://apps.who.int/iris/handle/10665/39644 [Link]

WHO Oral Health Country/Area Profile Programma (CAPP) Oral Health Manpower. http://www.mah.se/CAPP/Country-Oral-Health-Profiles/SEARO/Nepal/Oral-Health-Manpower/. Accessed on 6th of Nevember 2020. [Link]

Published
2021-07-29
How to Cite
1.
Jaiswal PK, Thakur P, Thapa K. Incidence of Oral Cancer in a Tertiary Cancer Centre of Nepal: A Retrospective Study. Europasian J Med Sci. [Internet]. 2021Jul.29 [cited 2024May13];3(2):4-. Available from: https://www.europasianjournals.org/ejms/index.php/ejms/article/view/256