Formulation and Evaluation of Fast Dissolving Oral Films of Cetirizine Hydrochloride
Objectives: This study was aimed to formulate and evaluate the fast dissolving oral films of Cetirizine Hydrochloride.
Methods: Oral films of Cetirizine Hydrochloride were prepared using HPMC, Polyvinyl alcohol, glycerol, aspartame in different concentrations by solvent casting method. Films were evaluated for different physical Films were subjected in USP dissolution studies.
Findings: The drug content of the nine formulations was found to be in the range as per Indian Pharmacopeia. In vitro release studies indicated 60-91% release within 30 min in the formulated oral films. The best release was found to be 91.58% of formulation F7 and minimum release was found to be 60.01% of formulation F1. Surface pH was found to be near to neutral (pH 7) which was good for buccal mucosa.
Conclusion: In this way the fixed ratio of plasticizer glycerin was used by varying the concentration of polymers polyvinyl alcohol and HPMC which varies in the release pattern of the films. High concentration of polymers decreased the release rate of cetirizine as in F1 and F2. Low concentration of polymers causes increment in the release rate of cetirizine as in F6 and F7. So by varying the concentration of polymers oral films can be formulated.
Keywords: Oral films, Cetirizine, HPMC, Polyvinyl alcohol, Solvent casting, Release rate.
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